DOT1L

Reference Set (77 Compounds)

CC(C)N(C[C@H]1O[C@@H](n2ccc3c(N)ncnc32)[C@H](O)[C@@H]1O)[C@H]1C[C@@H](CCc2nc3cc(C(C)(C)C)ccc3[nH]2)C1 ZINC000166456976

ZINC000166456976 (search)

CC(C)N(C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O)[C@H]1C[C@H](CCc2nc3cc(Cl)c(C(F)(F)F)cc3[nH]2)C1 ZINC000167949263

ZINC000167949263 (search)

CN(C[C@H]1O[C@@H](n2ccc3c(N)ncnc32)[C@H](O)[C@@H]1O)[C@H]1C[C@H](CCc2nc3cc(C(C)(C)C)ccc3[nH]2)C1 ZINC000166457109

ZINC000166457109 (search)

CC(C)N(C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O)[C@H]1C[C@@H](CCc2nc3cc(C(C)(C)C)ccc3[nH]2)C1 ZINC000100074350

ZINC000100074350 (search)

CC(C)N(C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O)[C@H]1C[C@H](CCc2nc3cc(C(C)(C)C)ccc3[nH]2)C1 ZINC000168212088

ZINC000168212088 (search)

CC(C)N(C[C@H]1O[C@@H](n2ccc3c(N)ncnc32)[C@H](O)[C@@H]1O)[C@H]1C[C@H](CCc2nc3cc(OC(F)(F)F)ccc3[nH]2)C1 ZINC000168379400

ZINC000168379400 (search)

CC(C)N(C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O)[C@H]1C[C@@H](CCc2nc3ccc(OC(F)(F)F)cc3[nH]2)C1 ZINC001772583489

ZINC001772583489 (search)

CN(C[C@H]1C[C@@H](n2ccc3c(N)ncnc32)[C@H](O)[C@@H]1O)[C@H]1C[C@H](CCc2nc3cc(C(C)(C)C)ccc3[nH]2)C1 ZINC000168011047

ZINC000168011047 (search)

CC(C)N(C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O)[C@H]1C[C@H](CCc2nc3ccc(OC(F)(F)F)cc3[nH]2)C1 ZINC001772617394

ZINC001772617394 (search)

CC(C)N(CCCNC(=O)Nc1ccc(C(C)(C)C)cc1)C[C@H]1O[C@@H](n2ccc3c(N)ncnc32)[C@H](O)[C@@H]1O ZINC000089469833

ZINC000089469833 (search)

CN(CCCNC(=O)Nc1ccc(C(C)(C)C)cc1)C[C@H]1O[C@@H](n2ccc3c(N)ncnc32)[C@H](O)[C@@H]1O ZINC000089469826

ZINC000089469826 (search)

CC(C)N(CCCNC(=O)Nc1nc2ccc(C(C)(C)C)cc2[nH]1)C[C@@H]1O[C@@H](n2ccc3c(N)ncnc32)[C@H](O)[C@@H]1O ZINC000169702057

ZINC000169702057 (search)

CC(C)(C)c1ccc(NC(=O)NCCCNC[C@@H]2O[C@H](n3ccc4c(N)ncnc43)[C@@H](O)[C@H]2O)cc1 ZINC000169702059

ZINC000169702059 (search)

CC(=O)N(CCCNC(=O)Nc1ccc(C(C)(C)C)cc1)C[C@@H]1O[C@H](n2ccc3c(N)ncnc32)[C@@H](O)[C@H]1O ZINC000169702060

ZINC000169702060 (search)

CC(C)N(CCCNC(=O)Nc1ccc(C(C)(C)C)cc1)C[C@H]1O[C@@H](n2cc(Br)c3c(N)ncnc32)[C@H](O)[C@@H]1O ZINC000097956664

ZINC000097956664 (search)

CC(C)N(C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O)C1CC(CCc2nc3cc(C(C)(C)C)ccc3[nH]2)C1 ZINC000098043806

ZINC000098043806 (search)

Cc1ncccc1-c1c(Cl)sc2ccc(NC(=O)NCC(=O)NCCCN(C)[C@@H]3CCCN(c4ncnc5[nH]ccc45)C3)cc12 ZINC001772572733

ZINC001772572733 (search)

CN(CCCNC(=O)CNC(=O)Nc1ccc2ccn(-c3ccccc3Cl)c2c1)[C@@H]1CCCN(c2ncnc3[nH]ccc23)C1 ZINC001772650993

ZINC001772650993 (search)

CC(C)N(CCCNC(=O)Nc1ccc(C(C)(C)C)cc1)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O ZINC000095557720

ZINC000095557720 (search)

CNc1ncnc2c1ncn2[C@@H]1O[C@H](CN(CCCNC(=O)Nc2ccc(C(C)(C)C)cc2)C(C)C)[C@@H](O)[C@H]1O ZINC000095553299

ZINC000095553299 (search)

CC(C)N(CCCNC(=O)Nc1ccc(C(C)(C)C)cc1)C[C@H]1C[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O ZINC000103293048

ZINC000103293048 (search)

CC(C)N(CCCNC(=O)Nc1ccc(C(C)(C)C)cc1)CC1=C[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O ZINC000103293046

ZINC000103293046 (search)

O=C(CNC(=O)Nc1ccc2ccn(-c3ccccc3Cl)c2c1)NCCCCN[C@@H]1CCCN(c2ncnc3[nH]ccc23)C1 ZINC001772578353

ZINC001772578353 (search)

O=C(CNC(=O)Nc1ccc2ccn(-c3ccccc3Cl)c2c1)NCCCN[C@@H]1CCCN(c2ncnc3[nH]ccc23)C1 ZINC001772609555

ZINC001772609555 (search)

CC(C)N(CCCNC(=O)Nc1ccc(C(C)(C)C)cc1)[C@@H](C)[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O ZINC001772623508

ZINC001772623508 (search)

C=CCNc1ncnc2c1ncn2[C@@H]1O[C@H](CN(CCCNC(=O)Nc2ccc(C(C)(C)C)cc2)C(C)C)[C@@H](O)[C@H]1O ZINC000095556691

ZINC000095556691 (search)

CN(CCCNC(=O)Nc1ccc(C(C)(C)C)cc1)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O ZINC000087613174

ZINC000087613174 (search)

CC(C)N(CCCNC(=O)Nc1ccc(C(C)(C)C)cc1)C[C@H]1O[C@@H](n2cnc3c(NCc4ccccc4)ncnc32)[C@H](O)[C@@H]1O ZINC000095553362

ZINC000095553362 (search)

Nc1ncnc2c1ncn2[C@@H]1O[C@H](CN(CCI)CCC[C@H](N)C(=O)O)[C@@H](O)[C@H]1O ZINC000103295987

ZINC000103295987 (search)

Nc1ncnc2c1c(Br)cn2[C@@H]1O[C@H](CSCC[C@H](N)C(=O)O)[C@@H](O)[C@H]1O ZINC000095604133

ZINC000095604133 (search)

Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCCNC(=O)Nc2ccc(C(F)(F)F)cc2)[C@@H](O)[C@H]1O ZINC000095555276

ZINC000095555276 (search)

CC(C)(C)c1ccc(NC(=O)NCCCSC[C@H]2O[C@@H](n3cnc4c(N)ncnc43)[C@H](O)[C@@H]2O)cc1 ZINC000103293051

ZINC000103293051 (search)

CNc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCCNC(=O)Nc2ccc(C(C)(C)C)cc2)[C@@H](O)[C@H]1O ZINC000095552332

ZINC000095552332 (search)

Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCCNC(=O)Nc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H](O)[C@H]1O ZINC000095555495

ZINC000095555495 (search)

Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCCNC(=O)Nc2ccc(Cl)cc2)[C@@H](O)[C@H]1O ZINC000095555162

ZINC000095555162 (search)

N[C@@H](CCCN(CCI)C[C@H]1O[C@@H](n2cnc3c(NCc4ccccc4)ncnc32)[C@H](O)[C@@H]1O)C(=O)O ZINC000095555570

ZINC000095555570 (search)

CNc1ncnc2c1ncn2[C@@H]1O[C@H](CN(CCI)CCC[C@H](N)C(=O)O)[C@@H](O)[C@H]1O ZINC000095556974

ZINC000095556974 (search)

CCc1cccc(NC(=O)NCCCSC[C@H]2O[C@@H](n3cnc4c(N)ncnc43)[C@H](O)[C@@H]2O)c1 ZINC000095553824

ZINC000095553824 (search)

Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCCNC(=O)Nc2ccc(OC(F)(F)F)cc2)[C@@H](O)[C@H]1O ZINC000095552302

ZINC000095552302 (search)

Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCC[C@H](N)C(=O)O)[C@@H](O)[C@H]1O ZINC000004228232

ZINC000004228232 (search)

Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCCNC(=O)Nc2ccc(Br)cc2)[C@@H](O)[C@H]1O ZINC000095553440

ZINC000095553440 (search)

Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCCNC(=O)Nc2ccc(I)cc2)[C@@H](O)[C@H]1O ZINC000095556177

ZINC000095556177 (search)

CNc1ncnc2c1ncn2[C@@H]1O[C@H](CSCC[C@H](N)C(=O)O)[C@@H](O)[C@H]1O ZINC000013522181

ZINC000013522181 (search)

CC(C)c1ccc(NC(=O)NCCCSC[C@H]2O[C@@H](n3cnc4c(N)ncnc43)[C@H](O)[C@@H]2O)cc1 ZINC000095556941

ZINC000095556941 (search)

Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCCNC(=O)Nc2ccccc2)[C@@H](O)[C@H]1O ZINC000095554462

ZINC000095554462 (search)

C[C@H](NC1CC(CCc2nc3ccc(C(C)(C)C)cc3[nH]2)C1)[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O ZINC001772657799

ZINC001772657799 (search)

CCc1ccccc1NC(=O)NCCCSC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O ZINC000095555958

ZINC000095555958 (search)

Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCCNC(=O)Nc2ccc(F)cc2F)[C@@H](O)[C@H]1O ZINC000095557569

ZINC000095557569 (search)

Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCCCNC(=O)Nc2ccccc2)[C@@H](O)[C@H]1O ZINC000095556264

ZINC000095556264 (search)

N[C@@H](CCSC[C@H]1O[C@@H](n2cnc3c(NCc4ccccc4)ncnc32)[C@H](O)[C@@H]1O)C(=O)O ZINC000038576043

ZINC000038576043 (search)

Cc1cccc(-c2nnc3sc(/C=C/c4ccco4)nn23)c1 ZINC000005345901

ZINC000005345901 (search)

NC(=O)c1cccc(CCN(CCC[C@H](N)C(=O)O)C[C@H]2O[C@@H](n3cnc4c(N)ncnc43)[C@H](O)[C@@H]2O)c1 ZINC001772625300

ZINC001772625300 (search)

C[C@@H]([C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O)N(C1CCC1)C1CC(CCc2nc3ccc(C(C)(C)C)cc3[nH]2)C1 ZINC001772601180

ZINC001772601180 (search)

Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCCNC(=O)NCc2ccccc2)[C@@H](O)[C@H]1O ZINC000095552639

ZINC000095552639 (search)

N[C@@H](CCSC[C@H]1O[C@@H](n2cnc3c(NC4CC4)ncnc32)[C@H](O)[C@@H]1O)C(=O)O ZINC000095553770

ZINC000095553770 (search)

C=CCNc1ncnc2c1ncn2[C@@H]1O[C@H](CSCC[C@H](N)C(=O)O)[C@@H](O)[C@H]1O ZINC000095555813

ZINC000095555813 (search)

C[C@@H]([C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O)N(C1CC(CCc2nc3ccc(C(C)(C)C)cc3[nH]2)C1)C1CC(CCc2nc3ccc(C(C)(C)C)cc3[nH]2)C1 ZINC001772583446

ZINC001772583446 (search)

Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCCNC(=O)Nc2cccc3ccccc23)[C@@H](O)[C@H]1O ZINC000095555552

ZINC000095555552 (search)

CCCCNc1ncnc2c1ncn2[C@@H]1O[C@H](CSCC[C@H](N)C(=O)O)[C@@H](O)[C@H]1O ZINC000038281040

ZINC000038281040 (search)

CC(C)Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCC[C@H](N)C(=O)O)[C@@H](O)[C@H]1O ZINC000095556698

ZINC000095556698 (search)

c1ccc2c(c1)nnn2Cc1nnc2sc(-c3ccc4c(c3)OCO4)nn12 ZINC000004867942

ZINC000004867942 (search)

Brc1cccc(-c2nn3c(Cn4cnc5ccccc54)nnc3s2)c1 ZINC000001016496

ZINC000001016496 (search)

CC(C)(C)c1ccc(-c2nn3c(Cn4nnc5ccccc54)nnc3s2)cc1 ZINC000005322272

ZINC000005322272 (search)

Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCCNC(=O)NC2CCCCC2)[C@@H](O)[C@H]1O ZINC000095555142

ZINC000095555142 (search)

Fc1ccc(-c2nn3c(Cn4nnc5ccccc54)nnc3s2)cc1 ZINC000002365829

ZINC000002365829 (search)

$C(=C/c1nn2c(-c3ccccc3)nnc2s1)\c1ccco1 ZINC000045208950$

ZINC000045208950 (search)

Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCCNC(=O)NCc2ccco2)[C@@H](O)[C@H]1O ZINC000095557376

ZINC000095557376 (search)

COc1cccc(-c2nn3c(Cn4nnc5ccccc54)nnc3s2)c1 ZINC000002360119

ZINC000002360119 (search)

CC(C)CCNc1ncnc2c1ncn2[C@@H]1O[C@H](CSCC[C@H](N)C(=O)O)[C@@H](O)[C@H]1O ZINC000095554124

ZINC000095554124 (search)

COc1ccccc1-c1nnc2sc(/C=C/c3ccco3)nn12 ZINC000004664942

ZINC000004664942 (search)

$C(=C/c1nn2c(-c3ccncc3)nnc2s1)\c1ccco1 ZINC000006668088$

ZINC000006668088 (search)

CC(C)(C)Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCC[C@H](N)C(=O)O)[C@@H](O)[C@H]1O ZINC000036418584

ZINC000036418584 (search)

NC(=O)CNC(=O)Nc1ccc2ccn(-c3ccccc3Cl)c2c1 ZINC001772618411

ZINC001772618411 (search)

Fc1cccc(-c2nn3c(Cn4nnc5ccccc54)nnc3s2)c1 ZINC000002433975

ZINC000002433975 (search)

c1ccc2c(c1)nnn2Cc1nnc2sc(-c3ccc4c(c3)OCCO4)nn12 ZINC000002879384

ZINC000002879384 (search)

CC(C)(C)CNc1ncnc2c1ncn2[C@@H]1O[C@H](CSCC[C@H](N)C(=O)O)[C@@H](O)[C@H]1O ZINC000095556656

ZINC000095556656 (search)

CN(C)c1ccc(-c2nnc3sc(/C=C/c4ccco4)nn23)cc1 ZINC000004414499

ZINC000004414499 (search)