NLRP3

Reference Set (75 Compounds)

O=C(Nc1cccc(Cl)c1)c1cc(N=Nc2ccc([N+](=O)[O-])cc2Cl)ccc1O ZINC000263596914

ZINC000263596914 (search)

Cc1cccc(C(=O)NNC(=O)c2c(O)c3ccccc3n(C)c2=O)c1 ZINC000100695633

ZINC000100695633 (search)

COc1c(OC(C)=O)c(=O)n2c3ccccc3c3ccnc1c32 ZINC000036383966

ZINC000036383966 (search)

O=C(Nc1ccc(Cl)cc1)Nc1ccc(Cl)c(Cl)c1 ZINC000000121480

ZINC000000121480 (search)

CC(=O)Oc1c(I)cc(I)cc1C(=O)Nc1ccc(Cl)cc1 ZINC000004215387

ZINC000004215387 (search)

c1ccc([C@@H]2Nc3ccccc3[C@H]3OCCC[C@@H]32)cc1 ZINC000001629790

ZINC000001629790 (search)

O=C(CCS(=O)(=O)c1ccccc1)N(CCCN1CCOCC1)c1nc2c(F)cccc2s1 ZINC000022997486

ZINC000022997486 (search)

CCN(CC)c1ccc2nc3ccc(=N)cc-3n(-c3ccccc3)c2c1 ZINC000138876050

ZINC000138876050 (search)

CC(C)NC(=O)c1c(O)c2ccccc2[nH]c1=O ZINC000013129929

ZINC000013129929 (search)

CCSc1nsc(NC(=O)Nc2cccc(F)c2)n1 ZINC000004898320

ZINC000004898320 (search)

COc1ccc(NC(=O)C#Cc2ccccc2)cc1 ZINC000006741573

ZINC000006741573 (search)

Cn1c(=O)c(C(=O)NNC(=O)c2ccccc2F)c(O)c2ccccc21 ZINC000100551275

ZINC000100551275 (search)

$Cc1cccc(C(=O)O/N=C(\N)Cc2cccc3ccccc23)c1 ZINC000004191365$

ZINC000004191365 (search)

Cc1ccc(NC(=O)c2nc(S(=O)(=O)Cc3ccccc3)ncc2Cl)cc1 ZINC000006748076

ZINC000006748076 (search)

CCCCCNC(=O)C(=O)[C@H]1C(=O)Nc2ccccc21 ZINC000100560627

ZINC000100560627 (search)

O=C(NC(=S)NNC(=O)c1ccccc1O)c1ccc(F)cc1 ZINC000002316476

ZINC000002316476 (search)

O=c1cc(-c2ccccc2Cl)oc2ccc([N+](=O)[O-])c(O)c12 ZINC000008680120

ZINC000008680120 (search)

O=C(NCCCCc1ccccc1)c1ccccc1Br ZINC000002493706

ZINC000002493706 (search)

CN(CC(=O)N1CCc2ccccc2C1)c1ccccc1 ZINC000003273100

ZINC000003273100 (search)

O=C(NCCC1=CCCCC1)c1c(O)nc2sccn2c1=O ZINC000096298835

ZINC000096298835 (search)

Cc1csc2nc(O)c(C(=O)NCCC3=CCCCC3)c(=O)n12 ZINC000010166699

ZINC000010166699 (search)

O=c1c2cc(Br)ccc2nc(-c2ccc([N+](=O)[O-])cc2)n1O ZINC000001382213

ZINC000001382213 (search)

O=C(NCCCc1ccccc1)c1c(O)nc2sccn2c1=O ZINC000016690014

ZINC000016690014 (search)

O=c1c2ccc(Cl)cc2nc(-c2cccc(C(F)(F)F)c2)n1O ZINC000005428077

ZINC000005428077 (search)

O=c1c2cc(Cl)ccc2nc(-c2ccc([N+](=O)[O-])cc2)n1O ZINC000006883679

ZINC000006883679 (search)

C[C@H]1CC(=O)c2cnc(Nc3cccc(C(F)(F)F)c3)nc2C1 ZINC000009328974

ZINC000009328974 (search)

CCCOc1ccc(C(=O)NNC(=S)NC(=O)c2cccs2)cc1 ZINC000002316520

ZINC000002316520 (search)

N#Cc1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1 ZINC000000125230

ZINC000000125230 (search)

COc1ccc(CNC(=O)c2c(C)oc3c2C(=O)c2ccccc2C3=O)cc1 ZINC000002700659

ZINC000002700659 (search)

CC[C@H]1Nc2ncnc(N3CCN(c4ccccn4)CC3)c2N(Cc2ccc(Cl)cc2)C1=O ZINC000036382448

ZINC000036382448 (search)

Cc1ccc(S(=O)(=O)N2CCN=C2SCc2ccccc2)cc1 ZINC000002711397

ZINC000002711397 (search)

Cn1c(=O)c(C(=O)Nc2ncccn2)c(O)c2ccccc21 ZINC000100534612

ZINC000100534612 (search)

CC[C@H]1Nc2ncnc(N3CCN(c4ccccn4)CC3)c2N(Cc2ccc(Br)cc2)C1=O ZINC000061959626

ZINC000061959626 (search)

O=C(Nc1cccc(Br)c1)c1cc2ccccc2o1 ZINC000000310170

ZINC000000310170 (search)

Oc1c(/C=N/c2ccccn2)sc2ccccc12 ZINC000018165250

ZINC000018165250 (search)

Cc1cccc(NC(=O)N2CCN(Cc3ccc(Cl)cc3)CC2)c1 ZINC000020408273

ZINC000020408273 (search)

O=C(Nc1scc(-c2ccccc2)c1C(=O)O)c1ccc(F)cc1 ZINC000004824973

ZINC000004824973 (search)

Cc1ccc(C2=NO[C@@](C)(c3nnc(-c4ccccc4)o3)C2)cc1 ZINC000012726958

ZINC000012726958 (search)

C[C@H](N)C(=O)OC(C)(C)Cc1ccc(Cl)cc1 ZINC000052969655

ZINC000052969655 (search)

O=C(Nc1cccc(Cl)c1)c1cnn2cccnc12 ZINC000002873936

ZINC000002873936 (search)

O=C(CN1CCCCC1)NNC(=O)c1cccc(Br)c1 ZINC000004866217

ZINC000004866217 (search)

COc1cccc(NC(=O)c2ccccc2)c1 ZINC000000128522

ZINC000000128522 (search)

$CC(=O)N(/N=C1\Sc2ccccc2C1=O)c1ccccc1C ZINC000012561994$

ZINC000012561994 (search)

Nc1ccc(Oc2cc(N)cc(Oc3ccccc3)c2)cc1 ZINC000000054410

ZINC000000054410 (search)

Cc1cccc(N2CCN(C[C@@H](O)COc3ccc(Cl)cc3)CC2)c1 ZINC000019923695

ZINC000019923695 (search)

CCC[C@H]1CCC(c2ccc(OCC)cc2)=CC1=O ZINC000000297511

ZINC000000297511 (search)

COc1cc(CNCCc2ccccc2)ccc1OCc1ccc(Cl)nc1 ZINC000002181885

ZINC000002181885 (search)

CN(CCOc1ccccc1)c1ccc(S(=O)(=O)N2CCCCC2)cn1 ZINC000023508329

ZINC000023508329 (search)

COc1ccc(-c2cc(=O)c3ccccc3o2)cc1 ZINC000000057689

ZINC000000057689 (search)

O=C(NNC(=S)NC(=O)c1ccc(Br)cc1)c1ccc([N+](=O)[O-])cc1 ZINC000002690709

ZINC000002690709 (search)

$C[C@@H]1C[C@@H]2O[C@H]2/C=C\C=C\C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1 ZINC000005492965$

ZINC000005492965 (search)

COc1ccccc1CNC(=O)c1ccc(SC)cc1OC ZINC000000337712

ZINC000000337712 (search)

CCOC(=O)N1C(=O)C2(CCCCC2)N(c2ccccc2Cl)C1=S ZINC000004406328

ZINC000004406328 (search)

c1ccc(OCc2nnnn2-c2ccccc2)cc1 ZINC000004387186

ZINC000004387186 (search)

CCN(CC)c1ccc2nc3ccccc3[n+](CC)c2c1 ZINC000004159281

ZINC000004159281 (search)

CCCCCCCCCn1c2c(c(=N)c3c1CCC3)CCC2 ZINC000002056004

ZINC000002056004 (search)

O=[N+]([O-])c1cccc(/C=N/Nc2nc(NCc3ccccc3)nc(N3CCOCC3)n2)c1O ZINC000013548917

ZINC000013548917 (search)

Cc1onc(-c2ccccc2Cl)c1C(=O)N1C=CC(C(F)(F)F)=NCC1 ZINC000001399097

ZINC000001399097 (search)

CCCCCC(=O)N1CCN(CC/N=C/C2C(=O)CC(c3ccco3)CC2=O)CC1 ZINC000006493107

ZINC000006493107 (search)

c1ccc(Sc2cccc3ccccc23)c(CNC2=NCCN2)c1 ZINC000000346645

ZINC000000346645 (search)

COc1ccc(-c2nn(-c3ccccc3)cc2C=O)cc1 ZINC000000293735

ZINC000000293735 (search)

CCCCCCCCn1c2c(c(=N)c3ccccc31)CCC2 ZINC000017545153

ZINC000017545153 (search)

C=CCc1c(C)nc(C)nc1N/N=C/c1ccccc1O ZINC000004763670

ZINC000004763670 (search)

CCOC(=O)c1ccc2c(c1)nc(COc1ccc(OC)cc1)n2CC ZINC000012620516

ZINC000012620516 (search)

CC(C)(O)c1coc(S(=O)(=O)NC(=O)Nc2c3c(cc4c2CCC4)CCC3)c1 ZINC000034025113

ZINC000034025113 (search)

CC(C)c1cc(Cl)cc(C(C)C)c1NC(=O)NS(=O)(=O)c1cccc([C@@H](C)O)c1 ZINC000135752486

ZINC000135752486 (search)

CC(C)(O)c1coc(S(=O)(=O)NC(=O)Nc2c3c(cc4c2[C@@H](O)CC4)CCC3)c1 ZINC001772652893

ZINC001772652893 (search)

CC(C)c1cc(Cl)cc(C(C)C)c1NC(=O)NS(=O)(=O)c1cccc(C(C)(C)O)c1 ZINC000137022819

ZINC000137022819 (search)

CC(C)(O)c1coc(S(=O)(=O)NC(=O)Nc2c3c(cc4c2CC[C@H]4O)CCC3)c1 ZINC001772617156

ZINC001772617156 (search)

O=C(/C=C/c1ccc(O)cc1)c1ccc(O)cc1O ZINC000003869608

ZINC000003869608 (search)

CC(C)(O)c1coc(S(=O)(=O)NC(=O)Nc2c3c(cc4c2C[C@@H](O)C4)CCC3)c1 ZINC001772578998

ZINC001772578998 (search)

$C=C1C(=O)C[C@@H]2[C@@H]3O[C@]3(C)CC/C=C(\C)CC[C@@H]12 ZINC000653720288$

ZINC000653720288 (search)

CC(=O)OC[C@@H]1C=CC(=O)CO1 ZINC000166437820

ZINC000166437820 (search)

CC(C)(O)c1coc(S(=O)(=O)NC(=O)Nc2c3c(cc4c2CC[C@@H]4O)CCC3)c1 ZINC001772639970

ZINC001772639970 (search)

O=C1C=C[C@H]2CO[C@@H]1O2 ZINC000000078169

ZINC000000078169 (search)