PTGS2

Reference Set (109 Compounds)

COc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(C)(=O)=O)cn2)cc1 ZINC000013588341

ZINC000013588341 (search)

CS(=O)(=O)c1ccc(-n2nc(C(F)F)c(Cl)c2-c2ccccc2)nc1 ZINC000013588365

ZINC000013588365 (search)

COc1ccc(-c2cc(C(F)F)nn2-c2ccc(S(C)(=O)=O)cn2)cc1F ZINC000013588357

ZINC000013588357 (search)

COc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(C)(=O)=O)cn2)c(F)c1 ZINC000013588349

ZINC000013588349 (search)

CS(=O)(=O)c1ccc(-n2nc(C(F)(F)F)c(Cl)c2-c2ccccc2)nc1 ZINC000013588364

ZINC000013588364 (search)

COc1ccc(-c2c(Cl)c(C(F)F)nn2-c2ccc(S(C)(=O)=O)cn2)cc1Cl ZINC000013588366

ZINC000013588366 (search)

COc1ccc(-c2cc(C(F)F)nn2-c2ccc(S(C)(=O)=O)cn2)cc1 ZINC000013588354

ZINC000013588354 (search)

CSc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(C)(=O)=O)cn2)cc1 ZINC000013588342

ZINC000013588342 (search)

CS(=O)(=O)c1ccc(-n2nc(C(F)F)c(Br)c2-c2ccccc2)nc1 ZINC000013588367

ZINC000013588367 (search)

CN(C)c1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(C)(=O)=O)cn2)cc1 ZINC000013588344

ZINC000013588344 (search)

CS(=O)(=O)c1ccc(-n2nc(C(F)F)cc2-c2ccc(Cl)cc2)nc1 ZINC000013588352

ZINC000013588352 (search)

CSc1ccc(-c2cc(C(F)F)nn2-c2ccc(S(C)(=O)=O)cn2)cc1 ZINC000013588355

ZINC000013588355 (search)

CCOc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(C)(=O)=O)cn2)cc1 ZINC000013588343

ZINC000013588343 (search)

COc1ccc(-c2cc(C(F)F)nn2-c2ccc(S(C)(=O)=O)cn2)cc1C ZINC000013588356

ZINC000013588356 (search)

Cc1c(C(F)(F)F)nn(-c2ccc(S(C)(=O)=O)cn2)c1-c1ccccc1 ZINC000013588368

ZINC000013588368 (search)

Cc1ccc(-c2cc(C(F)F)nn2-c2ccc(S(C)(=O)=O)cn2)cc1 ZINC000013588360

ZINC000013588360 (search)

Cc1c(C(F)F)nn(-c2ccc(S(C)(=O)=O)cn2)c1-c1ccccc1 ZINC000013588369

ZINC000013588369 (search)

CS(=O)(=O)c1ccc(-n2nc(C(F)(F)F)cc2-c2ccc(F)cc2)nc1 ZINC000013588338

ZINC000013588338 (search)

CS(=O)(=O)c1ccc(-n2nc(C(F)(F)F)cc2-c2ccc(Cl)cc2)nc1 ZINC000013588339

ZINC000013588339 (search)

COc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(C)(=O)=O)cn2)cc1C ZINC000013588345

ZINC000013588345 (search)

CS(=O)(=O)c1ccc(-n2nc(C(F)F)cc2-c2ccc(Br)cc2)nc1 ZINC000013588353

ZINC000013588353 (search)

COc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(C)(=O)=O)cn2)cc1Cl ZINC000013588347

ZINC000013588347 (search)

CS(=O)(=O)c1ccc(-n2nc(C(F)F)cc2-c2ccc(F)cc2)nc1 ZINC000013588351

ZINC000013588351 (search)

COc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(C)(=O)=O)cn2)cc1F ZINC000013588346

ZINC000013588346 (search)

COc1ccc(-c2cc(C(F)F)nn2-c2ccc(S(C)(=O)=O)cn2)cc1Cl ZINC000013588358

ZINC000013588358 (search)

COc1ccc(-c2cc(C(F)F)nn2-c2ccc(S(C)(=O)=O)cn2)c(F)c1 ZINC000013588359

ZINC000013588359 (search)

CCc1ccc(-c2cc(C(F)F)nn2-c2ccc(S(C)(=O)=O)cn2)cc1 ZINC000013588361

ZINC000013588361 (search)

CS(=O)(=O)c1ccc(-n2nc(C(F)(F)F)cc2-c2ccccc2)nc1 ZINC000013588337

ZINC000013588337 (search)

CS(=O)(=O)c1ccc(-n2nc(C(F)(F)F)cc2-c2ccc(Br)cc2)nc1 ZINC000013588340

ZINC000013588340 (search)

COc1ccc(-c2cc(C(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1F ZINC000000607803

ZINC000000607803 (search)

COc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(C)(=O)=O)cn2)cc1Br ZINC000013588348

ZINC000013588348 (search)

CCCc1ccc(-c2cc(C(F)F)nn2-c2ccc(S(C)(=O)=O)cn2)cc1 ZINC000013588362

ZINC000013588362 (search)

CC(C)c1ccc(-c2cc(C(F)F)nn2-c2ccc(S(C)(=O)=O)cn2)cc1 ZINC000013588363

ZINC000013588363 (search)

O=C(N[C@H]1CCC[C@@H]1OCc1ccccc1)C1CCN(c2nc3cc(Cl)ccc3o2)CC1 ZINC000095597058

ZINC000095597058 (search)

Cc1cc(-c2cc(C(F)(F)F)nn2-c2ccc(S(C)(=O)=O)cn2)ccc1-c1ccco1 ZINC000034393204

ZINC000034393204 (search)

CS(=O)(=O)c1ccc(-n2nc(C(F)F)cc2-c2ccc(-c3ccco3)c(Cl)c2)nc1 ZINC000034393425

ZINC000034393425 (search)

CS(=O)(=O)c1ccc(-n2nc(C(F)(F)F)cc2-c2ccc(-c3ccco3)c(Cl)c2)nc1 ZINC000028572587

ZINC000028572587 (search)

CS(=O)(=O)c1ccc(-n2nc(C(F)(F)F)cc2-c2ccc(-c3ccco3)c(C#N)c2)nc1 ZINC000036338757

ZINC000036338757 (search)

Cc1cc(-c2cc(C(F)F)nn2-c2ccc(S(C)(=O)=O)cn2)ccc1-c1cscn1 ZINC000028572214

ZINC000028572214 (search)

CS(=O)(=O)c1ccc(-n2nc(C(F)(F)F)cc2-c2ccc(-c3ccco3)cc2)nc1 ZINC000036338756

ZINC000036338756 (search)

C[C@@H]1CCCN(c2c(C#N)c(C(F)F)nn2-c2ccc(S(C)(=O)=O)cn2)C1 ZINC000028566252

ZINC000028566252 (search)

Cc1cc(-c2cc(C(F)(F)F)nn2-c2ccc(S(C)(=O)=O)cn2)ccc1-c1cocn1 ZINC000028572406

ZINC000028572406 (search)

CS(=O)(=O)c1ccc(-n2nc(C(F)(F)F)c(C#N)c2SCc2ccccc2F)nc1 ZINC000028569954

ZINC000028569954 (search)

CCCSc1c(C#N)c(C(F)(F)F)nn1-c1ccc(S(C)(=O)=O)cn1 ZINC000028569978

ZINC000028569978 (search)

CC[C@@H](C)Sc1c(C#N)c(C(F)(F)F)nn1-c1ccc(S(C)(=O)=O)cn1 ZINC000028570065

ZINC000028570065 (search)

CS(=O)(=O)c1ccc(-n2nc(C(F)(F)F)cc2-c2ccc(-c3ccco3)c(F)c2)nc1 ZINC000034243299

ZINC000034243299 (search)

CS(=O)(=O)c1ccc(-n2nc(C(F)(F)F)cc2-c2ccc(-c3cscn3)c(Cl)c2)nc1 ZINC000036338761

ZINC000036338761 (search)

CS(=O)(=O)c1ccc(-n2nc(C(F)(F)F)c(C#N)c2Sc2ccccc2)nc1 ZINC000028569873

ZINC000028569873 (search)

CS(=O)(=O)c1ccc(-n2nc(C(F)(F)F)c(C#N)c2OCC2CCCC2)nc1 ZINC000028570153

ZINC000028570153 (search)

CS(=O)(=O)c1ccc(-n2nc(C(F)F)cc2-c2ccc(-c3ccco3)c(F)c2)nc1 ZINC000036338760

ZINC000036338760 (search)

CS(=O)(=O)c1ccc(-n2nc(C(F)(F)F)c(C#N)c2NC[C@@H]2CCCO2)nc1 ZINC000028567818

ZINC000028567818 (search)

Cc1cc(-c2cc(C(F)(F)F)nn2-c2ccc(S(C)(=O)=O)cn2)ccc1-c1ncco1 ZINC000036338754

ZINC000036338754 (search)

CS(=O)(=O)c1ccc(-n2nc(C(F)(F)F)c(C#N)c2OC2CCCCCC2)nc1 ZINC000028570461

ZINC000028570461 (search)

CS(=O)(=O)c1ccc(-n2nc(C(F)(F)F)c(C#N)c2SCc2ccccc2)nc1 ZINC000028569872

ZINC000028569872 (search)

CS(=O)(=O)c1ccc(-n2nc(C(F)(F)F)c(C#N)c2OCC2CCC2)nc1 ZINC000028570051

ZINC000028570051 (search)

CC(C)[C@@H](C)Oc1c(C#N)c(C(F)(F)F)nn1-c1ccc(S(C)(=O)=O)cn1 ZINC000028569553

ZINC000028569553 (search)

C=C1CCC(COc2c(C#N)c(C(F)(F)F)nn2-c2ccc(S(C)(=O)=O)cn2)CC1 ZINC000028570239

ZINC000028570239 (search)

Cc1cc(-c2cc(C(F)(F)F)nn2-c2ccc(S(C)(=O)=O)cn2)ccc1-c1cscn1 ZINC000034311180

ZINC000034311180 (search)

C[C@@H]1C[C@@H](C)CN(c2c(C#N)c(C(F)(F)F)nn2-c2ccc(S(C)(=O)=O)cn2)C1 ZINC000028566090

ZINC000028566090 (search)

CS(=O)(=O)c1ccc(-n2nc(C(F)(F)F)c(C#N)c2SC2CCCCC2)nc1 ZINC000028570753

ZINC000028570753 (search)

CS(=O)(=O)c1ccc(-n2nc(C(F)(F)F)c(C#N)c2NCC2CC2)nc1 ZINC000028566112

ZINC000028566112 (search)

CC(C)COc1c(C#N)c(C(F)(F)F)nn1-c1ccc(S(C)(=O)=O)cn1 ZINC000028569560

ZINC000028569560 (search)

CS(=O)(=O)c1ccc(-n2nc(C(F)(F)F)cc2-c2ccc(-c3nccs3)c(C#N)c2)nc1 ZINC000036338763

ZINC000036338763 (search)

Cc1ccc(CNc2c(C#N)c(C(F)(F)F)nn2-c2ccc(S(C)(=O)=O)cn2)cc1 ZINC000028565438

ZINC000028565438 (search)

CS(=O)(=O)c1ccc(-n2nc(C(F)(F)F)c(C#N)c2NCc2cccs2)nc1 ZINC000028565460

ZINC000028565460 (search)

CS(=O)(=O)c1ccc(-n2nc(C(F)(F)F)c(C#N)c2NCC2OCCO2)nc1 ZINC000028566110

ZINC000028566110 (search)

CS(=O)(=O)c1ccc(-n2nc(C(F)F)c(C#N)c2N2CCCCCC2)nc1 ZINC000028566273

ZINC000028566273 (search)

CC(C)(C)CNc1c(C#N)c(C(F)(F)F)nn1-c1ccc(S(N)(=O)=O)cn1 ZINC000028566480

ZINC000028566480 (search)

CS(=O)(=O)c1ccc(-n2nc(C(F)F)cc2-c2ccc(-c3ccco3)cc2)nc1 ZINC000036338755

ZINC000036338755 (search)

CC(C)[C@@H](C)Nc1c(C#N)c(C(F)(F)F)nn1-c1ccc(S(C)(=O)=O)cn1 ZINC000028565957

ZINC000028565957 (search)

C[C@H]1CN(c2c(C#N)c(C(F)F)nn2-c2ccc(S(C)(=O)=O)cn2)C[C@@H](C)O1 ZINC000028563369

ZINC000028563369 (search)

C[C@H]1CN(c2c(C#N)c(C(F)(F)F)nn2-c2ccc(S(C)(=O)=O)cn2)C[C@@H](C)O1 ZINC000028567826

ZINC000028567826 (search)

CS(=O)(=O)c1ccc(-n2nc(C(F)(F)F)c(C#N)c2OC[C@H]2CC=CCC2)nc1 ZINC000028570155

ZINC000028570155 (search)

N#Cc1c(C(F)(F)F)nn(-c2ccc(S(N)(=O)=O)cn2)c1N[C@H]1C[C@H]2CC[C@H]1C2 ZINC000253639195

ZINC000253639195 (search)

CS(=O)(=O)c1ccc(-n2nc(C(F)(F)F)c(C#N)c2N[C@@H]2C[C@H]3CC[C@H]2C3)nc1 ZINC000253638306

ZINC000253638306 (search)

CS(=O)(=O)c1ccc(-n2nc(C(F)(F)F)c(C#N)c2N2CCCCC2)nc1 ZINC000028565753

ZINC000028565753 (search)

C[C@@H]1CC[C@@H](Oc2c(C#N)c(C(F)(F)F)nn2-c2ccc(S(C)(=O)=O)cn2)C1 ZINC000028570462

ZINC000028570462 (search)

CS(=O)(=O)c1ccc(-n2nc(C(F)(F)F)cc2-c2ccc(-c3cscn3)cc2)nc1 ZINC000036338764

ZINC000036338764 (search)

CCOCCSc1c(C#N)c(C(F)(F)F)nn1-c1ccc(S(C)(=O)=O)cn1 ZINC000028569979

ZINC000028569979 (search)

CC[C@@H](Oc1c(C#N)c(C(F)(F)F)nn1-c1ccc(S(C)(=O)=O)cn1)C(C)C ZINC000028570236

ZINC000028570236 (search)

Cc1cccc(Oc2c(C#N)c(C(F)(F)F)nn2-c2ccc(S(C)(=O)=O)cn2)c1C ZINC000028570752

ZINC000028570752 (search)

CS(=O)(=O)c1ccc(-n2nc(C(F)(F)F)cc2-c2ccc(-c3cncs3)cc2)nc1 ZINC000036338759

ZINC000036338759 (search)

CC[C@@H](C)CNc1c(C#N)c(C(F)(F)F)nn1-c1ccc(S(N)(=O)=O)cn1 ZINC000028563396

ZINC000028563396 (search)

CS(=O)(=O)c1ccc(-n2nc(C(F)F)c(C#N)c2NCC2OCCO2)nc1 ZINC000028566274

ZINC000028566274 (search)

CCC(CC)Nc1c(C#N)c(C(F)(F)F)nn1-c1ccc(S(C)(=O)=O)cn1 ZINC000028566311

ZINC000028566311 (search)

CC(C)(C)CNc1c(C#N)c(C(F)F)nn1-c1ccc(S(C)(=O)=O)cn1 ZINC000028563609

ZINC000028563609 (search)

CC[C@@H](C)CNc1c(C#N)c(C(F)F)nn1-c1ccc(S(N)(=O)=O)cn1 ZINC000028566307

ZINC000028566307 (search)

C[C@@H]1CCCC[C@@H]1Oc1c(C#N)c(C(F)(F)F)nn1-c1ccc(S(C)(=O)=O)cn1 ZINC000028569980

ZINC000028569980 (search)

C[C@H]1C[C@@H](C)CN(c2c(C#N)c(C(F)F)nn2-c2ccc(S(N)(=O)=O)cn2)C1 ZINC000028566336

ZINC000028566336 (search)

CS(=O)(=O)c1ccc(-n2nc(C(F)(F)F)c(C#N)c2OC2CCCC2)nc1 ZINC000028570050

ZINC000028570050 (search)

CS(=O)(=O)c1ccc(-n2nc(C(F)(F)F)cc2-c2ccc(-c3nccs3)cc2)nc1 ZINC000028572514

ZINC000028572514 (search)

CC(C)(C)CNc1c(C#N)c(C(F)(F)F)nn1-c1ccc(S(C)(=O)=O)cn1 ZINC000028565979

ZINC000028565979 (search)

CS(=O)(=O)c1ccc(-n2nc(C(F)(F)F)cc2-c2ccc(-c3cscn3)cc2F)nc1 ZINC000036338762

ZINC000036338762 (search)

C[C@@H]1CCCC[C@@H]1Nc1c(C#N)c(C(F)(F)F)nn1-c1ccc(S(C)(=O)=O)cn1 ZINC000028565738

ZINC000028565738 (search)

CCCCCSc1c(C#N)c(C(F)(F)F)nn1-c1ccc(S(C)(=O)=O)cn1 ZINC000028570071

ZINC000028570071 (search)

CS(=O)(=O)c1ccc(-n2nc(C(F)F)cc2-c2ccccc2)nc1 ZINC000013588350

ZINC000013588350 (search)

CC(C)Nc1c(C#N)c(C(F)(F)F)nn1-c1ccc(S(C)(=O)=O)cn1 ZINC000028563082

ZINC000028563082 (search)

CC(C)(C)CNc1c(C#N)c(C(F)F)nn1-c1ccc(S(N)(=O)=O)cn1 ZINC000028566476

ZINC000028566476 (search)

CC(C)CCCSc1c(C#N)c(C(F)(F)F)nn1-c1ccc(S(C)(=O)=O)cn1 ZINC000028570072

ZINC000028570072 (search)

CS(=O)(=O)c1ccc(-n2nc(C(F)(F)F)cc2-c2ccc(-c3ccco3)c(C(N)=O)c2)nc1 ZINC000036338758

ZINC000036338758 (search)

CS(=O)(=O)c1ccc(-n2nc(C(F)F)c(C#N)c2N[C@@H]2C[C@H]3CC[C@H]2C3)nc1 ZINC000253637590

ZINC000253637590 (search)

CCC(CC)Oc1c(C#N)c(C(F)(F)F)nn1-c1ccc(S(C)(=O)=O)cn1 ZINC000028570551

ZINC000028570551 (search)

CS(=O)(=O)c1ccc(-n2nc(C(F)(F)F)c(C#N)c2OC2CCC2)nc1 ZINC000028570469

ZINC000028570469 (search)

CS(=O)(=O)c1ccc(-n2nc(C(F)(F)F)c(C#N)c2Oc2cccc3c2CCCC3)nc1 ZINC000028570141

ZINC000028570141 (search)

N#Cc1c(C(F)(F)F)nn(-c2ccc(S(N)(=O)=O)cn2)c1NC[C@@H]1CCCO1 ZINC000028563111

ZINC000028563111 (search)

C[C@@H]1C[C@@H](C)CN(c2c(C#N)c(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cn2)C1 ZINC000028563400

ZINC000028563400 (search)

CC(C)COc1cc(C(F)(F)F)nn1-c1ccc(S(C)(=O)=O)cn1 ZINC000001494259

ZINC000001494259 (search)

C[C@H]1CN(c2c(C#N)c(C(F)F)nn2-c2ccc(S(N)(=O)=O)cn2)C[C@@H](C)O1 ZINC000028563386

ZINC000028563386 (search)

C[C@H]1CN(c2c(C#N)c(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cn2)C[C@@H](C)O1 ZINC000028566305

ZINC000028566305 (search)