TLR4

Reference Set (68 Compounds)

CCCOc1c2cc(NC(=N)N)cc1Cc1cc(NC(=N)N)cc(c1OCCC)Cc1cc(NC(=N)N)cc(c1OCCC)Cc1cc(cc(NC(=N)N)c1)C2 ZINC001772631648

ZINC001772631648 (search)

CCCCCCOc1c2cc(NC(=N)N)cc1Cc1cc(NC(=N)N)cc(c1OCCCCCC)Cc1cc(NC(=N)N)cc(c1OCCCCCC)Cc1cc(cc(NC(=N)N)c1)C2 ZINC001772590990

ZINC001772590990 (search)

CCOC(=O)C1=CCCC[C@H]1S(=O)(=O)Nc1ccc(F)cc1Cl ZINC000013982410

ZINC000013982410 (search)

CCOC(=O)C1=CCC[C@@H]1S(=O)(=O)Nc1ccc(F)cc1Cl ZINC000028638013

ZINC000028638013 (search)

CCOC(=O)C1=CCCC[C@@H]1S(=O)(=O)Nc1ccc(Cl)cc1F ZINC000028637594

ZINC000028637594 (search)

CCOC(=O)C1=CCCCC[C@@H]1S(=O)(=O)Nc1ccc(F)cc1Cl ZINC000028638017

ZINC000028638017 (search)

COc1ccc([C@H]2[C@H]3c4c(c5ccccc5[nH]c4=O)OC(C)(C)[C@H]3[C@@H]2C2CCCC2)cc1OC ZINC000169334524

ZINC000169334524 (search)

Cn1c2ccc(-c3ccccc3)cc2c2nc(SCC(=O)NC3CCCCC3)n(-c3ccccc3)c(=O)c21 ZINC001772589050

ZINC001772589050 (search)

COc1ccc([C@H]2[C@H]3c4c(c5ccccc5[nH]c4=O)OC(C)(C)[C@H]3[C@@H]2C(C)C)cc1OCCO ZINC000169334514

ZINC000169334514 (search)

CCCCCCCCCCCC(=O)N[C@H]1[C@@H](OP(=O)(O)O)O[C@H](CO)[C@@H](OP(=O)(O)O)[C@@H]1OC(=O)CCCCCCCCCCC ZINC001772623770

ZINC001772623770 (search)

COc1ccc([C@H]2[C@H]3c4c(c5ccccc5[nH]c4=O)OC(C)(C)[C@H]3[C@@H]2C2CC2)cc1OC ZINC000169334518

ZINC000169334518 (search)

COc1cc([C@H]2[C@H]3c4c(c5ccccc5[nH]c4=O)OC(C)(C)[C@H]3[C@@H]2C2CC2)cc(OC)c1OC ZINC000169334521

ZINC000169334521 (search)

COc1cc([C@H]2[C@H]3c4c(c5ccccc5[nH]c4=O)OC(C)(C)[C@H]3[C@@H]2C2CCCC2)cc(OC)c1OC ZINC000169334526

ZINC000169334526 (search)

CC[C@H]1[C@H]2[C@H](c3c(c4ccccc4[nH]c3=O)OC2(C)C)[C@@H]1c1cc(OC)c(OC)c(OC)c1 ZINC000169334497

ZINC000169334497 (search)

COc1cc([C@H]2[C@H]3c4c(c5ccccc5[nH]c4=O)OC(C)(C)[C@H]3[C@@H]2C(C)C)cc(OC)c1OC ZINC000169334499

ZINC000169334499 (search)

COc1ccc([C@H]2[C@H]3c4c(c5ccccc5[nH]c4=O)OC(C)(C)[C@H]3[C@@H]2C2CC2)cc1OCCCO ZINC000169334516

ZINC000169334516 (search)

COc1cc([C@H]2[C@H]3c4c(c5ccccc5n(C)c4=O)OC(C)(C)[C@H]3[C@@H]2C2CC2)cc(OC)c1OC ZINC000169338471

ZINC000169338471 (search)

Cn1c2ccc(-c3ccc4ccccc4c3)cc2c2nc(SCC(=O)NC3CCCCC3)n(-c3ccccc3)c(=O)c21 ZINC001772633796

ZINC001772633796 (search)

COc1ccc([C@H]2[C@H]3c4c(c5ccccc5[nH]c4=O)OC(C)(C)[C@H]3[C@@H]2C(C)C)cc1OC ZINC000169334506

ZINC000169334506 (search)

COc1ccc([C@H]2[C@H]3c4c(c5ccccc5n(C)c4=O)CC(C)(C)[C@H]3[C@@H]2C2CC2)cc1OC ZINC000169338473

ZINC000169338473 (search)

CC[C@H]1[C@H]2[C@H](c3c(c4ccccc4[nH]c3=O)OC2(C)C)[C@@H]1c1ccc(OC)c(OC)c1 ZINC000169334496

ZINC000169334496 (search)

CCCC[C@H]1[C@H]2[C@H](c3c(c4ccccc4[nH]c3=O)OC2(C)C)[C@@H]1c1ccc(OC)c(OC)c1 ZINC000169334531

ZINC000169334531 (search)

CCCCCCCCCCCCCC(=O)N[C@H]1[C@@H](OP(=O)(O)O)O[C@H](CO)[C@@H](OP(=O)(O)O)[C@@H]1OC(=O)CCCCCCCCCCCCC ZINC000208935737

ZINC000208935737 (search)

COc1ccc([C@H]2[C@H]3c4c(c5ccccc5[nH]c4=O)OC(C)(C)[C@H]3[C@@H]2C(C)C)cc1Cl ZINC000169334501

ZINC000169334501 (search)

COc1ccc([C@H]2[C@H]3c4c(c5ccccc5[nH]c4=O)OC(C)(C)[C@H]3[C@@H]2C(C)C)cc1CCl ZINC000169334503

ZINC000169334503 (search)

CCCC[C@H]1[C@H]2[C@H](c3c(c4ccccc4[nH]c3=O)OC2(C)C)[C@@H]1c1cc(OC)c(OC)c(OC)c1 ZINC000169334529

ZINC000169334529 (search)

CC[C@H]1[C@H]2[C@H](c3c(c4ccccc4n(C)c3=O)OC2(C)C)[C@@H]1c1ccc(OC)c(OC)c1 ZINC000169338452

ZINC000169338452 (search)

Cn1c2ccc(-c3cccc4ccccc34)cc2c2nc(SCC(=O)NC3CCCCC3)n(-c3ccccc3)c(=O)c21 ZINC001772582094

ZINC001772582094 (search)

COc1ccc([C@@H]2[C@@H](C)[C@H]3[C@@H]2c2c(c4ccccc4n(C)c2=O)OC3(C)C)cc1OC ZINC000169338450

ZINC000169338450 (search)

COc1cc([C@H]2[C@H]3c4c(c5ccccc5n(C)c4=O)CC(C)(C)[C@H]3[C@@H]2C2CCCC2)cc(OC)c1OC ZINC000169338475

ZINC000169338475 (search)

Nc1ccccc1Oc1ccc2c(N)nsc2c1 ZINC000003818486

ZINC000003818486 (search)

COc1ccc([C@@H]2[C@@H](C)[C@H]3[C@@H]2c2c(c4ccccc4[nH]c2=O)OC3(C)C)cc1OC ZINC000169334487

ZINC000169334487 (search)

COc1cc(OC)cc([C@@H]2[C@@H](C)[C@H]3[C@@H]2c2c(c4ccccc4[nH]c2=O)OC3(C)C)c1 ZINC000169334488

ZINC000169334488 (search)

COc1ccc([C@@H]2[C@@H](C)[C@H]3[C@@H]2c2c(c4ccccc4[nH]c2=O)OC3(C)C)c(Cl)c1OC ZINC000169334490

ZINC000169334490 (search)

COc1ccc([C@@H]2[C@@H](C)[C@H]3[C@@H]2c2c(c4ccccc4[nH]c2=O)OC3(C)C)cc1F ZINC000169334498

ZINC000169334498 (search)

CC[C@H]1[C@H]2[C@H](c3c(c4ccccc4n(C)c3=O)OC2(C)C)[C@@H]1c1ccc(OC)c(F)c1 ZINC000169338454

ZINC000169338454 (search)

CC[C@H]1[C@H]2[C@H](c3c(c4cc(C)ccc4n(C)c3=O)OC2(C)C)[C@@H]1c1cc(OC)c(OC)c(OC)c1 ZINC000169338456

ZINC000169338456 (search)

CC[C@H]1[C@H]2[C@H](c3c(c4cc(C)ccc4n(C)c3=O)OC2(C)C)[C@@H]1c1ccc(OC)c(OC)c1 ZINC000169338458

ZINC000169338458 (search)

COc1ccc([C@H]2[C@H]3c4c(c5ccccc5n(C)c4=O)OC(C)(C)[C@H]3[C@@H]2C(C)C)cc1Cl ZINC000169338465

ZINC000169338465 (search)

COc1ccc([C@H]2[C@H]3c4c(c5ccccc5n(C)c4=O)OC(C)(C)[C@H]3[C@@H]2C(C)C)cc1OC(C)=O ZINC000169338468

ZINC000169338468 (search)

CCC[C@]1(c2cc(OC)cc(OC)c2)O[C@H]2c3c(c4ccccc4[nH]c3=O)OC(C)(C)[C@H]2O1 ZINC000169338494

ZINC000169338494 (search)

C#Cc1ccc2c(c1)c1nc(SCC(=O)NC3CCCCC3)n(-c3ccccc3)c(=O)c1n2C ZINC001772603776

ZINC001772603776 (search)

CC(=O)[C@]1(O)CC[C@]2(O)[C@]3(O)CC=C4C[C@@H](OC(=O)CCl)CC[C@]4(C)[C@H]3C[C@@H](OC(=O)c3ccc(O)cc3)[C@]12C ZINC001772630805

ZINC001772630805 (search)

Cn1c2ccc(Br)cc2c2nc(SCC(=O)NC3CCCCC3)n(-c3ccccc3)c(=O)c21 ZINC001772640948

ZINC001772640948 (search)

CCCCCC(=O)O[C@@H]1[C@@H](CSCCNC(=S)NCCN(CCN)CCN)O[C@H](OC)[C@H](OC(=O)CCCCC)[C@H]1OC(=O)CCCCC ZINC000299829353

ZINC000299829353 (search)

Cn1c2ccc(I)cc2c2nc(SCC(=O)NC3CCCCC3)n(-c3ccccc3)c(=O)c21 ZINC001772627500

ZINC001772627500 (search)

COc1cc([C@@H]2[C@@H](C)[C@H]3[C@@H]2c2c(c4ccccc4[nH]c2=O)OC3(C)C)cc(OC)c1OC ZINC000169334484

ZINC000169334484 (search)

COc1ccc([C@@H]2[C@@H](C)[C@H]3[C@@H]2c2c(c4ccccc4[nH]c2=O)OC3(C)C)cc1Br ZINC000169334489

ZINC000169334489 (search)

CCOc1ccc([C@H]2[C@H]3c4c(c5ccccc5[nH]c4=O)OC(C)(C)[C@H]3[C@@H]2C(C)C)cc1OC ZINC000169334511

ZINC000169334511 (search)

COc1ccc([C@H]2[C@H]3c4c(c5ccccc5[nH]c4=O)OC(C)(C)[C@H]3[C@@H]2C2CC2)cc1OCCCN1CCOCC1 ZINC000169334522

ZINC000169334522 (search)

COc1ccc(/C=C/C(=O)O[C@H]2CC[C@@]3(C)C(=CC[C@]4(O)[C@@H]3C[C@@H](OC(=O)/C=C(\C)C(C)C)[C@]3(C)[C@](O)(C(C)=O)CC[C@]43O)C2)cc1 ZINC000084758225

ZINC000084758225 (search)

C[C@@H](OC(=O)c1ccccc1O)[C@]1(O)CC[C@]2(O)[C@]3(O)CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3C[C@@H](OC(=O)/C=C/c3ccccc3)[C@]12C ZINC001772587831

ZINC001772587831 (search)

COc1cc([C@@H]2[C@@H](COC(C)=O)[C@H]3[C@@H]2c2c(c4ccccc4[nH]c2=O)OC3(C)C)cc(OC)c1OC ZINC000169334541

ZINC000169334541 (search)

CCCCCCCCCC(=O)N[C@H]1[C@@H](OP(=O)(O)O)O[C@H](CO)[C@@H](OP(=O)(O)O)[C@@H]1OC(=O)CCCCCCCCC ZINC001772587501

ZINC001772587501 (search)

COc1ccc([C@H]2[C@H]3c4c(c5ccccc5[nH]c4=O)OC(C)(C)[C@H]3[C@@H]2C(C)C)cc1OC(=O)CCC(=O)O ZINC000169334508

ZINC000169334508 (search)

C[C@@H](OC(=O)c1cccnc1)[C@]1(O)CC[C@]2(O)[C@]3(O)C=CC4=CC(=O)C=C[C@]4(C)[C@H]3C[C@@H](OC(=O)/C=C/c3ccccc3)[C@]12C ZINC001772654108

ZINC001772654108 (search)

O=C(CSc1nc2c3c([nH]c2c(=O)n1-c1ccccc1)CCCCC3)NC1CCCCC1 ZINC001772640573

ZINC001772640573 (search)

COc1ccc([C@@H]2[C@@H](C(=O)C3CC3)[C@H]3[C@@H]2c2c(c4ccccc4[nH]c2=O)OC3(C)C)cc1OC ZINC000169334535

ZINC000169334535 (search)

COc1cc([C@H]2[C@H]3c4c(c5cc(C)ccc5n(C)c4=O)OC(C)(C)[C@H]3[C@@H]2C(C)C)cc(OC)c1OC ZINC000169338462

ZINC000169338462 (search)

Cn1c2ccccc2c2nc(SCC(=O)NC3CCCCC3)n(-c3ccccc3)c(=O)c21 ZINC000096922821

ZINC000096922821 (search)

COc1ccc([C@@H]2[C@@H](C(C)=O)[C@H]3[C@@H]2c2c(c4ccccc4[nH]c2=O)OC3(C)C)cc1OC ZINC000169334532

ZINC000169334532 (search)

CCCCCCCCCCCCCC(=O)N[C@@H](COCC[C@H](CCCCCCC)OC(=O)CCCCCCCCCCC)CO[P@@](=O)(O)OCCNC(=O)[C@@H](Cc1ccc(O)cc1)C(=O)O ZINC000150567334

ZINC000150567334 (search)

CCCCCCCCCCCCCC(=O)N[C@H](COCC[C@H](CCCCCCC)OC(=O)CCCCCCCCCCC)CO[P@@](=O)(O)OCCNC(=O)[C@@H](Cc1ccc(O)cc1)C(=O)O ZINC000150567376

ZINC000150567376 (search)

CCCCCCCCCCCCCC(=O)N[C@@H](COCC[C@@H](CCCCCCC)OC(=O)CCCCCCCCCCC)CO[P@@](=O)(O)OCCNC(=O)[C@@H](Cc1ccc(O)cc1)C(=O)O ZINC000150567343

ZINC000150567343 (search)

CCCCCCCCCCCCCC(=O)N[C@H](COCC[C@@H](CCCCCCC)OC(=O)CCCCCCCCCCC)CO[P@@](=O)(O)OCCNC(=O)[C@@H](Cc1ccc(O)cc1)C(=O)O ZINC000150551640

ZINC000150551640 (search)

CCCCCCCCOc1c(/C=N/N=C(N)N)ccc(/C=N/N=C(N)N)c1OCCCCCCCC ZINC000042923514

ZINC000042923514 (search)

CCCCCCOc1c(/C=N/N=C(N)N)ccc(/C=N/NC(=N)N)c1OCCCCCC ZINC000042965237

ZINC000042965237 (search)

CCCCOc1c(/C=N/N=C(N)N)ccc(/C=N/NC(=N)N)c1OCCCC ZINC000042964528

ZINC000042964528 (search)