Trpv4

Reference Set (73 Compounds)

CCOc1ccc2c(C(=O)NC3(c4ccccc4)CC3)c(CN3CCC(N4CCCCC4)CC3)c(-c3cccc(C(F)(F)F)c3)nc2c1 ZINC000199368745

ZINC000199368745 (search)

O=C(NC1(c2ccccc2)CC1)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2cccc(C(F)(F)F)c2)nc2cc(Br)ccc12 ZINC000098052705

ZINC000098052705 (search)

Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4[C@H]5CC[C@H]4CN(c4ncc(C(F)(F)F)cn4)C5)cn3)n2)s1 ZINC001772654687

ZINC001772654687 (search)

O=C(N[C@H](c1ccccc1)C(F)(F)F)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2cccc(C(F)(F)F)c2)nc2ccc(Br)cc12 ZINC000164935584

ZINC000164935584 (search)

O=C(NC1(c2ccccc2)CC1)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2cccc(C(F)(F)F)c2)nc2ccccc12 ZINC000199367723

ZINC000199367723 (search)

COc1ccc2c(C(=O)NC3(c4ccccc4)CC3)c(CN3CCC(N4CCCCC4)CC3)c(-c3cccc(C(F)(F)F)c3)nc2c1 ZINC000199380420

ZINC000199380420 (search)

C[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2cccc(C(F)(F)F)c2)nc2ccccc12)c1ccccc1 ZINC001503886526

ZINC001503886526 (search)

O=C(N[C@H](c1ccccc1)C(F)(F)F)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2cccc(C(F)(F)F)c2)nc2ccccc12 ZINC001772609491

ZINC001772609491 (search)

CCOc1ccc2c(C(=O)N[C@H](c3ccccc3)C(F)(F)F)c(CN3CCC(N4CCCCC4)CC3)c(-c3cccc(C(F)(F)F)c3)nc2c1 ZINC000165240098

ZINC000165240098 (search)

O=C(N[C@H](c1ccccc1)C(F)(F)F)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2cccc(C(F)(F)F)c2)nc2cc(Br)ccc12 ZINC001772637219

ZINC001772637219 (search)

C[C@H](NC(=O)c1c(CN2CCC(N3CCOCC3)CC2)c(-c2cccc(C(F)(F)F)c2)nc2ccccc12)c1ccccc1 ZINC000118751188

ZINC000118751188 (search)

COc1ccc2c(C(=O)N[C@H](c3ccccc3)C(F)(F)F)c(CN3CCC(N4CCCCC4)CC3)c(-c3cccc(C(F)(F)F)c3)nc2c1 ZINC001772624951

ZINC001772624951 (search)

Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4[C@H]5COC[C@H]4CN(c4ncc(C(F)(F)F)cn4)C5)cn3)n2)s1 ZINC001772632290

ZINC001772632290 (search)

CC[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2cccc(C(F)(F)F)c2)nc2ccccc12)c1ccccc1 ZINC001772622058

ZINC001772622058 (search)

O=C(N[C@@H](c1ccccc1)C(F)(F)F)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2cccc(C(F)(F)F)c2)nc2ccccc12 ZINC001772593506

ZINC001772593506 (search)

C[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2cccc(Cl)c2)nc2ccccc12)c1ccccc1 ZINC001772596627

ZINC001772596627 (search)

Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4CCN(c5ncc(C(F)(F)F)cn5)C[C@H]4C(F)(F)F)cn3)n2)s1 ZINC001772599911

ZINC001772599911 (search)

Cc1cccc(-c2nc3ccccc3c(C(=O)N[C@@H](C)c3ccccc3)c2CN2CCC(N3CCCCC3)CC2)c1 ZINC001772584657

ZINC001772584657 (search)

COC(=O)N1CCN(C(=O)c2ccc(Nc3nc(-c4sc(C)nc4C)cs3)nc2)[C@H](C(F)(F)F)C1 ZINC001772633596

ZINC001772633596 (search)

C[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2ccc(Cl)cc2)nc2ccccc12)c1ccccc1 ZINC001772605631

ZINC001772605631 (search)

C[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2ccc(C(F)(F)F)cc2)nc2ccccc12)c1ccccc1 ZINC001772610776

ZINC001772610776 (search)

Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4[C@H]5CC[C@H]4CN(c4ncc(Cl)cn4)C5)cn3)n2)s1 ZINC001772596337

ZINC001772596337 (search)

Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4[C@H]5CC[C@@H]4CC(=NOCC(F)(F)F)C5)cn3)n2)s1 ZINC001772602146

ZINC001772602146 (search)

Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4[C@H]5CC[C@H]4CN(c4ccc(Cl)cn4)C5)cn3)n2)s1 ZINC001772648151

ZINC001772648151 (search)

Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4CCN(c5ncc(C(F)(F)F)cn5)C[C@@H]4C)cn3)n2)s1 ZINC001772593990

ZINC001772593990 (search)

CC(C)[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2cccc(C(F)(F)F)c2)nc2ccccc12)c1ccccc1 ZINC001772605740

ZINC001772605740 (search)

Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4[C@H]5CC[C@@H]4CC(=NOC[C@@H](O)C(F)(F)F)C5)cn3)n2)s1 ZINC001772629393

ZINC001772629393 (search)

CC(C)Nc1nc2c(C(=O)N(C)C)c(Cl)c(Cl)cc2n1C1CCN(c2ccc(C(C)(C)C#N)cc2)CC1 ZINC000095581540

ZINC000095581540 (search)

N#Cc1ccc(OCC2(O)CN(S(=O)(=O)c3ccc(Cl)cc3Cl)C2)cc1F ZINC000169330771

ZINC000169330771 (search)

Cc1nc([C@@H](C)O)sc1-c1csc(Nc2ccc(C(=O)N3[C@H]4CC[C@H]3CN(c3ncc(C(F)(F)F)cn3)C4)cn2)n1 ZINC001772616729

ZINC001772616729 (search)

Cc1cc(-c2csc(Nc3ccc(C(=O)N4[C@H]5CC[C@H]4CN(c4ncc(C(F)(F)F)cn4)C5)cn3)n2)n(C)n1 ZINC001772581863

ZINC001772581863 (search)

CC(C)(NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2cccc(C(F)(F)F)c2)nc2ccccc12)c1ccccc1 ZINC001772616917

ZINC001772616917 (search)

Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4CCN(c5ncc(C(F)(F)F)cn5)[C@@H](C)C4)cn3)n2)s1 ZINC001772643019

ZINC001772643019 (search)

Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4C[C@@H]5CC[C@H](C4)N5c4ncc(C(F)(F)F)cn4)cn3)n2)s1 ZINC001772573899

ZINC001772573899 (search)

O=C(NCc1ccccc1)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2cccc(C(F)(F)F)c2)nc2ccccc12 ZINC001772583853

ZINC001772583853 (search)

COC(=O)N1C[C@@H]2CC[C@H](C1)N2C(=O)c1ccc(Nc2nc(-c3sc(C)nc3C)cs2)nc1 ZINC001772583000

ZINC001772583000 (search)

Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4[C@H]5CC[C@@H]4CC(=NOCCCO)C5)cn3)n2)s1 ZINC001772573057

ZINC001772573057 (search)

Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4[C@H]5CC[C@@H]4CC(=NOC4CCN(C)CC4)C5)cn3)n2)s1 ZINC001772581760

ZINC001772581760 (search)

Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4CCN(c5ncc(C(F)(F)F)cn5)C[C@H]4C)cn3)n2)s1 ZINC001772648923

ZINC001772648923 (search)

Cc1ccc(-c2nc3ccccc3c(C(=O)N[C@@H](C)c3ccccc3)c2CN2CCC(N3CCCCC3)CC2)cc1 ZINC001772619819

ZINC001772619819 (search)

Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4[C@H]5CNC[C@H]4COC5)cn3)n2)s1 ZINC001772605337

ZINC001772605337 (search)

Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4[C@H]5CC[C@@H]4C[C@H](Oc4ncc(C(F)(F)F)cn4)C5)cn3)n2)s1 ZINC001772623082

ZINC001772623082 (search)

CC(C)N1CCN(S(=O)(=O)c2ccc(NC(=O)c3ccc(C(F)(F)F)cc3[N+](=O)[O-])cc2)CC1 ZINC000473113885

ZINC000473113885 (search)

Cc1c(C(=O)Nc2cccc(C(F)(F)F)c2)cc(-c2ccccc2)n1CCCN1CCOCC1 ZINC000020224140

ZINC000020224140 (search)

Cc1nn(C)cc1-c1nsc(Nc2ccc(C(=O)N3[C@H]4CC[C@H]3CN(c3ncc(C(F)(F)F)cn3)C4)cn2)n1 ZINC001772576666

ZINC001772576666 (search)

Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4[C@H]5CC[C@@H]4C[C@H](OCCO)C5)cn3)n2)s1 ZINC001772571462

ZINC001772571462 (search)

Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4[C@H]5CC[C@@H]4C[C@H](OC(=O)NCCF)C5)cn3)n2)s1 ZINC001772618174

ZINC001772618174 (search)

C[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 ZINC000230600158

ZINC000230600158 (search)

C[C@H](NC(=O)c1c(CN2CCC(N(C)C)CC2)c(-c2cccc(C(F)(F)F)c2)nc2ccccc12)c1ccccc1 ZINC001772571743

ZINC001772571743 (search)

COc1ccc(-c2nc3ccccc3c(C(=O)N[C@@H](C)c3ccccc3)c2CN2CCC(N3CCCCC3)CC2)cc1 ZINC001772655157

ZINC001772655157 (search)

Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4[C@H]5CC[C@H]4CC(=O)C5)cn3)n2)s1 ZINC001772655902

ZINC001772655902 (search)

CC(C)N1CCN(S(=O)(=O)c2ccc(NC(=O)c3ccc(C(F)(F)F)cc3F)cc2)CC1 ZINC000473116470

ZINC000473116470 (search)

CC(C)N1CCN(S(=O)(=O)c2ccc(NC(=O)c3ccc(S(F)(F)(F)(F)F)cc3)cc2)CC1 ZINC000473114100

ZINC000473114100 (search)

Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4[C@H]5CC[C@H]4CN(c4ccc(Cl)cc4)C5)cn3)n2)s1 ZINC001772606098

ZINC001772606098 (search)

CC(C)N1CCN(S(=O)(=O)c2ccc(NC(=O)c3ccc(C(F)(F)F)cc3C(F)(F)F)cc2)CC1 ZINC000473116250

ZINC000473116250 (search)

CC(=O)N1C[C@@H]2CC[C@H](C1)N2C(=O)c1ccc(Nc2nc(-c3sc(C)nc3C)cs2)nc1 ZINC001772618238

ZINC001772618238 (search)

COc1cccc(-c2nc3ccccc3c(C(=O)N[C@@H](C)c3ccccc3)c2CN2CCC(N3CCCCC3)CC2)c1 ZINC001772573990

ZINC001772573990 (search)

C[C@@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 ZINC001772590837

ZINC001772590837 (search)

C[C@H](NC(=O)c1c(CN2CCC(N3CCNCC3)CC2)c(-c2cccc(C(F)(F)F)c2)nc2ccccc12)c1ccccc1 ZINC001772606693

ZINC001772606693 (search)

Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4[C@H]5COC[C@H]4CC(=O)C5)cn3)n2)s1 ZINC001772576060

ZINC001772576060 (search)

CC(C)N1CCN(S(=O)(=O)c2ccc(NC(=O)c3ccc(C(F)(F)F)cc3)cc2)CC1 ZINC000473117332

ZINC000473117332 (search)

Cc1nc(C)c(-c2csc(Nc3ccc(C(=O)N4[C@H]5CC[C@@H]4C[C@H](O)C5)cn3)n2)s1 ZINC001772651844

ZINC001772651844 (search)

CC(C)N1CCN(S(=O)(=O)c2ccc(NC(=O)c3ccc(C(C)(C)C)cc3)cc2)CC1 ZINC000473114973

ZINC000473114973 (search)

COC(=O)N1CCN(C(=O)c2ccc(Nc3nc(-c4sc(C)nc4C)cs3)nc2)CC1 ZINC001772579743

ZINC001772579743 (search)

N#Cc1ccc(OCC2(O)CCN(S(=O)(=O)c3ccc(Cl)cc3Cl)CC2)cc1 ZINC000169329151

ZINC000169329151 (search)

CC(C)N1CCN(S(=O)(=O)c2ccc(NC(=O)c3cccc(C(F)(F)F)c3)cc2)CC1 ZINC000473114969

ZINC000473114969 (search)

CC(C)N1CCN(S(=O)(=O)c2ccc(NC(=O)c3ccc(C(F)(F)F)cc3N)cc2)CC1 ZINC000473111387

ZINC000473111387 (search)

CC(C)NCCN(C(C)C)S(=O)(=O)c1ccc(Cl)cc1Cl ZINC000002582197

ZINC000002582197 (search)

CC(C)N1CCN(S(=O)(=O)c2ccc(NC(=O)c3ccc(-c4ncccc4Cl)cc3)cc2)CC1 ZINC000147889005

ZINC000147889005 (search)

CC(C)N1CCN(S(=O)(=O)c2ccc(NC(=O)c3ccccc3)cc2)CC1 ZINC000473111274

ZINC000473111274 (search)

CN(C)S(=O)(=O)c1ccc(NC(=O)c2ccc(C(F)(F)F)cc2)cc1 ZINC000002660448

ZINC000002660448 (search)

CC(C)N1CCN(S(=O)(=O)c2ccc(NC(=O)c3ccc(-c4ccccn4)cc3)cc2)CC1 ZINC000148174074

ZINC000148174074 (search)

CCCc1cc(O)c2c(c1)OC(C)(C)c1ccc(C)cc1-2 ZINC000013383067

ZINC000013383067 (search)